https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44806 Wed 01 May 2024 12:05:04 AEST ]]> Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46094 1 and FVC. Trends towards similar clinical associations with elevated MCs were observed in a paucigranulocytic subpopulation (n = 15) lacking airway eosinophilia or neutrophilia. Receiver operator characteristic (ROC) analysis showed peripheral blood eosinophil (PBE) count predicted elevated sputum eosinophils and basophils, but not MCs. Conclusions and Clinical Relevance: Sputum MCs are elevated in asthma, and their measurement may be useful as they relate to key clinical features of asthma (spirometry, asthma control, AHR). PBE count did not predict airway MC status, suggesting direct measurement of airway MCs by sensitive methods such as flow cytometry should be further developed.]]> Tue 21 May 2024 11:55:14 AEST ]]> Molecular markers of type 2 airway inflammation are similar between eosinophilic severe asthma and eosinophilic chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49105 Tue 14 Nov 2023 14:40:06 AEDT ]]> Neutrophilic asthma features increased airway classical monocytes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47276 Mon 27 Mar 2023 13:58:24 AEDT ]]> Appropriate use of oral corticosteroids for severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43398 Mon 04 Sep 2023 13:18:03 AEST ]]>